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Ludovic Martin, MD, PhD

Ludovic Martin

Head, Department of Dermatology and the PXE Referral Centre
Angers University Hospital, Angers, France

Ludovic Martin, MD, PhD, is a French dermatologist with a long-standing interest in PXE (clinical care and basic research). He graduated with a degree in medicine (1998) after having worked on the biology of dermal elastic fibers. He then completed his PhD dedicated to PXE (2006). As a Professor of Dermatology, he is the head of both the Dept. of Dermatology and the PXE referral centre in Angers University Hospital. From the academic side, he is in a research team at Angers Medical School that works on several animal models of arteriopathy, including that of Abcc6 -/- mice. Dr. Martin lives in Angers, a very pleasant, history-rich, French city not far from the Atlantic Ocean, with his wife Isabelle and their two daughters, Hélène and Emmanuelle.



Areas of Interest

Genetics of PXE, PXE Animal Models, PXE and the Metabolism, Clinical Manifestations, Epidemiology of PXE, Clinical Trials



Kauffenstein G, Pizard A, Le Corre Y, Vessières E, Grimaud L, Toutain B, Labat C, Mauras Y, Gorgels TG, Bergen AA, Le Saux O, Lacolley P, Lefthériotis G, Henrion D, Martin L. Disseminated arterial calcification and enhanced myogenic response are associated with abcc6 deficiency in a mouse model of pseudoxanthoma elasticum. Arterioscler Thromb Vasc Biol. 2014 May;34(5):1045-56. PMID: 24675664 

Leftheriotis G, Kauffenstein G, Hamel JF, Abraham P, Le Saux O, Willoteaux S, Henrion D, Martin L. The contribution of arterial calcification to peripheral arterial disease in pseudoxanthoma elasticum. PLoS One. 2014 May 6;9(5):e96003. Free article in PubMed. PMID: 24800819 

Bière L, Donal E, Terrien G, Furber A, Martin L, Prunier F. Left ventricular function in a large cohort of pseudoxanthoma elasticum patients. PLoS One. 2014 Mar 20;9(3):e90364. Free PMC Article. PMID: 24651258

Ebran JM, Milea D, Trelohan A, Bonicel P, Hamel JF, Leftheriotis G, Martin L. New insights into the visual prognosis of pseudoxanthoma elasticum. Br J Ophthalmol. 2014 Jan;98(1):142-3. PMID: 24123906

Brampton C, Aherrahrou Z, Chen LH, Martin L, Bergen AA, Gorgels TG, Erdfdi J, Schunkert H, Szabó Z, Váradi A, Le Saux O. The level of hepatic ABCC6 expression determines the severity of calcification after cardiac injury. Am J Pathol. 2014 Jan;184(1):159-70. PMID: 24479134

Guérin-Moreau M, Leftheriotis G, Le Corre Y, Etienne M, Amode R, Hamel JF, Croué A, Le Saux O, Machet L, Martin L. High frequency (20-50 MHz) ultrasonography of pseudoxanthoma elasticum skin lesions. Br J Dermatol. 2013 Dec;169(6):1233-9. PMID: 23909384

Ferré M, Reynier P, Chevrollier A, Prunier-Mirebeau D, Lefthériotis G, Henrion D, Bonneau D, Procaccio V, Martin L. Is ABCC6 a genuine mitochondrial protein? BMC Res Notes. 2013 Oct 23;6:427. Free article in PubMed PMID: 24152371

Prunier F, Terrien G, Le Corre Y, Apana AL, Bière L, Kauffenstein G, Furber A, Bergen AA, Gorgels TG, Le Saux O, Leftheriotis G, Martin L. Pseudoxanthoma elasticum: Cardiac findings in patients and Abcc6-deficient mouse model. PLoS One. 2013 Jul 23;8(7):e68700. Free article in PubMed. PMID: 23935882

Pomozi V, Le Saux O, Brampton C, Apana A, Iliás A, Szeri F, Martin L, Monostory K, Paku S, Sarkadi B, Szakács G, Váradi A. ABCC6 is a basolateral plasma membrane protein. Circ Res. 2013 May 24;112(11):e148-51. Free article in PubMed. PMID: 23625951

Trelohan A, Milea D, Martin L, Leftheriotis G, Ebran JM. Myopia in pseudoxanthoma elasticum. J Fr Ophthalmol. 2013 May;36(5):414-7. PMID: 23510649

Lefthériotis G, Omarjee L, Le Saux O, Henrion D, Abraham P, Prunier F, Willoteaux S, Martin L. The vascular phenotype in pseudoxanthoma elasticum and related disorders: contribution of a genetic disease to the understanding of vascular calcification. Front Genet. 2013 Feb 12;4:4. Free article in PubMed. PMID: 23408347

Le Saux O, Martin L, Aherrahrou Z, Lefthériotis G, Váradi A, Brampton CN. The molecular and physiological roles of ABCC6: more than meets the eye. Frontiers in Genetics. 2012 Dec 12;3:289. Article here. PMID: 23248644

Le Corre Y, Le Saux O, Froeliger F, Libouban H, Kauffenstein G, Willoteaux S, Leftheriotis G, Martin L. Quantification of the calcification phenotype of Abcc6-deficient mice with microcomputed tomography. The American Journal of Pathology. 2012 Jun;180(6):2208-13. PMID: 22469843

Dannepond C, Martin L, Kerdraon R, Croué A, Lebidre E, Estève E. Atypical eruptive collagenoma: Two cases. Ann Dermatol Venereol. 2012 Mar;139(3):209-15. [In French]. PMID: 22401687

Nitschke Y, Baujat G, Botschen U, Wittkampf T, du Moulin M, Stella J, Le Merrer M, Guest G, Lambot K, Tazarourte-Pinturier M, Chassaing N, Roche O, Feenstra I, Loechner K, D Charu, Garber S., Chikarmane R, Steinmann B, Shahinyan T, Martorell L, Davies J, Smith W, Kahler S, Mignon McCulloch M, Wraige E, Loidi L, Höhne W, Martin L, Hadj-Rabia S, Terkeltaub R, Rutsch F. Generalized arterial calcification of infancy and pseudoxanthoma elasticum can be caused by mutations in either ENPP1 or ABCC6. Am J Hum Gen. 2012 Jan;90(1):25-39. Free article in PubMed. PMID: 22209248

Lefthériotis G, Abraham P, Le Corre Y, Le Saux O, Henrion D, Ducluzeau Ph, Prunier F, Martin L. Relationship between ankle brachial index and arterial remodeling in pseudoxanthoma elasticum. J Vasc Surg. 2011 Nov;54(5):1390-4. PMID: 21723076

Vasseur M, Carsin-Nicol B, Ebran JM, Willoteaux S, Martin L, Lefthériotis G; on the behalf of the Angers PXE Consultation Center group. Carotid rete mirabile and pseudoxanthoma elasticum: an accidental association? Eur J Vasc Endovasc Surg. 2011 Sep;42(3):292-4. PMID: 21723754

Trélohan A, Martin L, Milea D, Bonicel P, Ebran Jm. 4. Retinal lesions in pseudoxanthoma elasticum: 51 patients. J Fr Ophtalmol. 2011 Sep;34(7):456-67. PMID: 21722988

Brampton C, Yamaguchi Y, Vanakker O, Van Laer L, Chen Lh, Thakore M, De Paepe A, Pomozi V, Szabó Pt, Martin L, Váradi A, Le Saux O. Vitamin K does not prevent soft tissue mineralization in a mouse model of pseudoxanthoma elasticum. Cell Cycle. 2011 Jun 1;10(11):1810-20. Patient summaryFree article in PubMed. PMID: 21597330

Lefthériotis G, Vanakker O, Le Saux O, Martin L. Reply to the article of C. Markello et al. entitled Vascular pathology of medial arterial calcifications in Nt5e deficiency: Implications for the role of adenosine in pseudoxanthoma elasticum. Mol Genet Metab. 2011 Jun;103(2):199-200. PMID: 21497121

Bercovitch L, Martin L, Chassaing N, Heffron TW, Bessis D, Vanakker V, Terry SF. Acquired pseudoxanthoma elasticum presenting after liver transplantation. J Am Acad Dermatol. 2011 May;64(5):873-8. Lay summaryFree article in PubMed. PMID: 21397982

Martin L, Douet V, VanWart CM, Heller MB, Le Saux O. A mouse model of β-thalassemia shows a liver-specific down-regulation of Abcc6 expression. Am J Pathol. 2011 Feb;178(2):774-83. Free article in PubMed. PMID: 21281810

Vanakker OM, Martin L, Schurgers LJ, Quaglino D, Vermeer C, Pasquali-Ronchetti I, Coucke PJ, De Paepe A. Low serum vitamin K in PXE results in defective carboxylation of mineralization inhibitors similar to GGCX mutations in the PXE-like syndrome. Lab Invest. 2010 Jun;90(6):895-905. PMID: 20368697

Costrop LM, Vanakker OM, Van Laer L, Le Saux O, Martin L, Chassaing N, Guerra D, Pasquali-Ronchetti I, Coucke PJ, De Paepe A. Novel deletions causing pseudoxanthoma elasticum underscore the genomic instability of the ABCC6 region. J Hum Genet. 2010 Feb;55(2):112-7. PMID: 20075945

Le Boulanger G, Labreze C, Croue A, Schurgers LJ, Chassaing N, Wittkampf T, Rutsch F, Martin L. An unusual severe vascular case of pseudoxanthoma elasticum presenting as generalized arterial calcification of infancy. Am J Med Genet - A. 2010 Jan;152A(1):118-23. PMID: 20034067

Naouri M, Boisseau C, Bonicel P, Daudon P, Bonneau D, Chassaing N, Martin L. Manifestations of pseudoxanthoma elasticum in childhood. Br J Dermatol. 2009 Sep;161(3):635-9. PMID: 19519828

Nozzi L, Grenier De Cardenal D, El Alamy F, Duyninh T, Martin L. Prévalence des atteintes de la muqueuse orale et du parodonte au cours du pseudoxanthome élastique. Ann Dermatol Venereol. 2008 Mar;135(3):183-6. PMID: 18374848

Martin L, Maitre F, Bonicel P, Daudon P, Verny C, Bonneau D, Le Saux O, Chassaing N. Heterozygosity for a single mutation in the ABCC6 gene may closely mimic PXE. Consequences of this phenotype overlap for the definition of PXE. Arch Dermatol. 2008 Mar;144(3):301-6. PMID: 18347285
Chassaing N, Martin L, Bourthoumieu S, Calvas P, Hovnanian A. Contribution of ABCC6 genomic rearrangements for the diagnosis of pseudoxanthoma elasticum in French patients. Human Mutat. 2007 Oct;28(10):1046 (mutation in brief #980 online). PMID: 17823974

Naouri M, Michenet P, Chassaing N, Martin L. Immunohistochemical characterization of elastofibroma and exclusion of ABCC6 as a predisposing gene. Br J Dermatol. 2007 Apr;156(4):755-8. PMID: 17493076

Martin L, Chassaing N, Delaite D, Estève E, Maître F, Le Bert M. Histological skin changes in heterozygote carriers of mutations in ABCC6, the gene causing pseudoxanthoma elasticum. J Eur Acad Dermatol Venereol. 2007 Mar;21(3):368-73. PMID: 17309461

Vanakker OM, Martin L, Gheduzzi D, Leroy BP, Loeys B, Guerci VI, Matthys D, Terry S, Coucke PJ, Pasquali-Ronchetti I, De Paepe A. Pseudoxanthoma elasticum-like phenotype with cutis laxa and multiple coagulation factor deficiency represents a separate genetic entity. J Invest Dermatol. 2007 Mar;127(3):581-7. Free article at Journal Website. PMID: 17110937

Martin L, Pissard S, Blanc P, Chassaing N, Legac E, Briault S, Le Bert M, Le Saux O. Augmentation de l’hémoglobine A2 au cours du pseudoxanthome élastique. Ann Dermatol Venereol. 2006 Aug-Sep;133(8-9 Pt 1):645-51. PMID: 17053732

Le Saux O, Bunda S, Van Wart CM, Douet V, Got L, Martin L, Hinek A. Serum factors from pseudoxanthoma elasticum patients alter elastic fiber formation in vitro. J Invest Dermatol. 2006 Jul;126(7):1497-505. PMID: 16543900

Cattan D, Bouali B, Chassaing N, Martinez F, Dupont JM, Dode C, Martin L. Early and severe amyloidosis in a patient with concurrent familial Mediterranean fever and pseudoxanthoma elasticum. Br J Dermatol. 2006 Jun;154(6):1190-3. PMID: 16704654

Nguyen LD, Terbah M, Daudon P, Martin L. Left ventricular systolic and diastolic function by echocardiogram in pseudoxanthoma elasticum. Am J Cardiol. 2006 May 15;97(10):1535-7. PMID: 16679100

Chassaing N, Martin L, Calvas P, Le Bert M, Hovnanian A. Pseudoxanthoma elasticum: a clinical, pathophysiological and genetic update including 11 novel ABCC6 mutations. J Med Genet. 2005 Dec;42(12):881-92. Free article in PubMed. PMID: 15894595

Chassaing N, Martin L, Mazereeuw J, Barrié L, Nizard S, Bonafé JL, Calvas P, Hovnanian A. Novel ABCC6 mutations in pseudoxanthoma elasticum. J Invest Dermatol. 2004 Mar;122(3):608-13. Free article at Journal Website. PMID: 15086542

Martin L, Le Saux O. News in pseudoxanthoma elasticum. Ann Dermatol Venereol. 2001 Sep;128(8-9):938-42. PMID: 11590352



Last modified: 09/01/2014