Mark Lebwohl, MD

Developed by Dr. Mark Lebwohl, a clinical trial exploring the effects of supplementary dietary magnesium on the progression of cutaneous and ocular signs in PXE is now underway.

Mark Lebwohl

Professor and Chairman
Department of Dermatology
The Mount Sinai School of Medicine, New York, NY

Dr. Mark Lebwohl graduated summa cum laude from Columbia College in 1974 and graduated from Harvard Medical School in 1978. He completed residencies in internal medicine and dermatology, both at Mount Sinai.

Dr. Lebwohl has been practicing dermatology since 1983. He is professor and chairman of the Department of Dermatology of The Mount Sinai School of Medicine. Dr. Lebwohl has served as president of the New York Dermatological Society, the Manhattan Dermatologic Society, and the New York State Society of Dermatology, and as chairman of the Dermatology Section of the New York Academy of Medicine. Dr. Lebwohl has served as chairman of the Psoriasis Task Force of the American Academy of Dermatology, and has directed the AAD’s annual Psoriasis Symposium, Diagnostic Update Symposium and Therapeutics Symposium. He was a member of the Scientific Assembly Council, and chaired Academy 2001 in California and the AAD annual meeting in Washington, D.C. in 2004. He was elected to the Board of Directors of the AAD for 2010-2014.

Dr. Lebwohl is on the editorial board of the Journal of the American Academy of Dermatology and is editor of the Dermatology Section of Scientific American Medicine, now called ACP Medicine. Dr. Lebwohl has chaired numerous symposia and has written, edited, or co-edited several books including the first atlas devoted entirely to cutaneous manifestations of systemic disease, and the leading book on dermatologic therapy, Treatment of Skin Disease. The second edition of The Skin and Systemic Disease has been published in English and in French, and English, Chinese, Portuguese, and Polish versions of Treatment of Skin Disease have been published. Other books include Difficult Diagnoses in Dermatology, Psoriasis, Mild-to-Moderate Psoriasis and Moderate-to-Severe Psoriasis. He has authored or co-authored over 500 publications including peer-reviewed articles, invited articles and book chapters. Dr. Lebwohl is actively involved in clinical trials of many new dermatologic treatments.

Areas of Interest

Clinical Manifestations, Clinical Trials



Yoo F, Blum R, Singer GK, Stern DK, Emanuel PO, Fuchs W, Phelps RG, Terry SF, Lebwohl MG. A randomized controlled trial of oral phosphate binders in the treatment of pseudoxanthoma elasticum. J Am Acad Dermatol. 2011 Aug;65(2):341-8. PMID: 21496949

Ringpfeil F, McGuigan K, Fuchsel L, Kozic H, Larralde M, Lebwohl M, Uitto J. Pseudoxanthoma elasticum is a recessive disease characterized by compound heterozygosity. J Invest Dermatol. 2006 Apr;126(4):782-6.  Free article at Journal Website. PMID: 16410789

Sherer DW, Singer G, Uribarri J, Phelps RG, Sapadin AN, Freund KB, Yanuzzi L, Fuchs W, Lebwohl M. Oral phosphate binders in the treatment of pseudoxanthoma elasticum. J Am Acad Dermatol. 2005 Oct;53(4):610-5. PMID: 16198780

Miksch S, Lumsden A, Guenther UP, Foernzler D, Christen-Zäch S, Daugherty C, Ramesar RK, Lebwohl M, Hohl D, Neldner KH, Lindpaintner K, Richards RI, Struk B. Molecular genetics of pseudoxanthoma elasticum: type and frequency of mutations in ABCC6. Hum Mutat. 2005 Sep;26(3):235-48. PMID: 16086317

Galadari H, Lebwohl M. Pseudoxanthoma elasticum: Temporary treatment of chin folds and lines with injectable collagen. J Am Acad Dermatol. 2003 Nov;49(5 Suppl):S265-6. PMID: 14576648

Lebwohl M, Lebwohl E, Bercovitch L. Prominent mental (chin) crease: a new sign of pseudoxanthoma elasticum. J Am Acad Dermatol. 2003 Apr;48(4):620-2.  Patient Summary. PMID: 12664032

Bercovitch L, Schepps B, Koelliker S, Magro C, Terry S, Lebwohl M. Mammographic findings in pseudoxanthoma elasticum. J Am Acad Dermatol. 2003 Mar;48(3):359-66.  Patient Summary. PMID: 12637915

Sherer DW, Bercovitch L, Lebwohl M. Pseudoxanthoma elasticum: significance of limited phenotypic expression in parents of affected offspring. J Am Acad Dermatol. 2001 Mar;44(3):534-7. PMID: 11209132

Ringpfeil F, Lebwohl MG, Uitto J. Abstracts: mutations in the MRP6 gene cause pseudoxanthoma elasticum. J Invest Dermatol. 2000 Aug;115(2):332. Free article at Journal Website. PMID: 10951257

Buka R, Wei H, Sapadin A, Mauch J, Lebwohl M, Rudikoff D. Pseudoxanthoma elasticum and calcinosis cutis. J Am Acad Dermatol. 2000 Aug;43(2 Pt 1):312-5. PMID: 10906658

Ringpfeil F, Lebwohl MG, Christiano AM, Uitto J. Pseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter. Proc Natl Acad Sci U S A. 2000 May 23;97(11):6001-6.  Free Article at PubMed. PMID: 10811882

Cai L, Struk B, Adams MD, Ji W, Haaf T, Kang HL, Dho SH, Xu X, Ringpfeil F, Nancarrow J, Zäch S, Schaen L, Stumm M, Niu T, Chung J, Lunze K, Verrecchia B, Goldsmith LA, Viljoen D, Figuera LE, Fuchs W, Lebwohl M, Uitto J, Richards R, Hohl D, Ramesar R. A 500-kb region on chromosome 16p13.1 contains the pseudoxanthoma elasticum locus: high-resolution mapping and genomic structure. J Mol Med. 2000 Mar;78(1):36-46. Free article at Journal Website. PMID: 10759028

Le Saux O, Urban Z, Göring HH, Csiszar K, Pope FM, Richards A, Pasquali-Ronchetti ITerry SBercovitch LLebwohl MG, Breuning M, van den Berg P, Kornet L, Doggett N, Ott J, de Jong PT, Bergen AA, Boyd CD. Pseudoxanthoma elasticum maps to an 820-kb region of the p13.1 region of chromosome 16. Genomics. 1999 Nov 15;62(1):1-10. PMID: 10585762

Uitto J, Boyd C, Lebwohl M, Moshell A, Rosenbloom J, and Terry SF. International centennial meeting on pseudoxanthoma elasticum: progress in PXE research. J Invest Dermatol. 1998 May;110(5):840-2. Free article at Journal WebsitePMID: 9579557

Lebwohl M, Neldner K, Pope FM, De Paepe A, Christiano AM, Boyd CD, Uitto J, McKusick VA. Classification of pseudoxanthoma elasticum: report of a consensus conference. J Am Acad Dermatol. 1994 Jan;30(1):103-7. Free article. PMID: 8277008