Tamás Arányi, MD, PhD


Tamas Aranyi

Senior Research Fellow
Institute of Enzymology, Hungarian Academy of Sciences  
Budapest, Hungary


Tamás Arányi, MD, PhD, obtained his medical degree at the Semmelweis University, Budapest, Hungary in 1998. He followed his studies in Paris, France at the University Pierre et Marie Curie and obtained his PhD degree in 2003 in molecular neuroscience. He then joined professor András Váradi’s laboratory at the Institute of Enzymology, Hungarian Academy of Sciences as a postdoctoral fellow. Since then he has been interested in the transcriptional and epigenetic regulation and evolution of the human ABCC6 gene as well as its association with clinical phenotypes. He published several papers in the field, presented his data at the PXE research meeting in 2004, twice at the Annual North American ABC Research Meeting and three times at the biannual FEBS ABC Special meeting. He attended some of these meetings with a PXE fellowship and was a PXE fellow in 2004-2005. Currently he is a senior research fellow and supervises the PhD studies of Hugues de Boussac and the work of Dr. Caroline Bacquet, postdoctoral fellow in professor András Váradi’s laboratory.

 


Areas of Interest


Genetics of PXE

 


Publications


Arányi T, Bacquet C, de Boussac H, Ratajewski M, Pomozi V, Fülöp K, Brampton CN, Pulaski L, Le Saux O, Váradi A. Transcriptional regulation of the ABCC6 gene and the background of impaired function of missense disease-causing mutations. Front Genet. 2013;4:27. Free article in PubMed. PMID: 23483032

Ratajewski M, de Boussac H, Sachrajda I, Bacquet C, Kovacs T, Váradi A, Pulaski L, Arányi T. ABCC6 expression is regulated by CCAAT/enhancer-binding protein activating a primate-specific sequence located in the first intron of the gene. J Invest Dermatol. 2012 Dec;132(12):2709-17. Free article in PubMed. PMID: 22763786

Fülöp K, Jiang Q, Wetering KV, Pomozi V, Szabó PT, Arányi T, Sarkadi B, Borst P, Uitto J, Váradi A. ABCC6 does not transport vitamin K3-glutathione conjugate from the liver: relevance to pathomechanisms of pseudoxanthoma elasticum. Biochem Biophys Res Commun. 2011 Nov 25;415(3):468-71. Free article in PubMed. PMID: 22056557

Le Saux O, Fülöp K, Yamaguchi Y, Iliás A, Szabó Z, Brampton CN, Pomozi V, Huszár K, Arányi T, Váradi A. Expression and in vivo rescue of human ABCC6 disease-causing mutants in mouse liver. PLoS One. 2011 Sep;6(9):e24738. Free article in PubMed. PMID: 21935449

Váradi A, Szabo Z., Pomozi V, De Boussac H, Fulop K., Arányi T. Abcc6 as a target in pseudoxanthoma elasticum. Curr Drug Targets. 2011 May;12(5):671-82. Free article in PubMed. PMID: 21039331

de Boussac H, Ratajewski M, Sachrajda I, Köblös G, Tordai A, Pulaski L, Buday L, Váradi A, Arányi T. The ERK1/2-hepatocyte nuclear factor 4alpha axis regulates human ABCC6 gene expression in hepatocytes. J Biol Chem 2010 Jul;285(30):22800-8. Free article in PubMed. PMID: 20463007

Köblös G, Andrikovics H, Prohászka Z, Tordai A, Váradi A, Arányi T. The R1141X loss-of-function mutation of the ABCC6 gene is a strong genetic risk factor for coronary artery disease. Genet Test Mol Biomarkers. 2010 Feb;14(1):75-8. Free article in PubMed. PMID: 19929409

Symmons O, Váradi A, Arányi T. How segmental duplications shape our genome: recent evolution of ABCC6 and PKD1 Mendelian disease genes. Mol Biol Evol. 2008 Dec;25(12):2601-13. Free article at Journal Website. PMID: 18791038

Arányi T, Ratajewski M, Bardóczy V, Pulaski L, Bors A, Tordai A, Váradi A. Identification of a DNA methylation-dependent activator sequence in the pseudoxanthoma elasticum gene, ABCC6. J Biol Chem. 2005 May 13;280(19):18643-50. Free article at Journal Website. PMID: 15760889