Koen van de Wetering, PhD, DVM

Division of Molecular Oncology
The Netherlands Cancer Institute, Amsterdam, Netherlands

Koen van de Wetering (1972) studied Veterinary Medicine in Utrecht (DVM) and got his PhD for work on the lung surfactant system in the group of Bert van Golde. In 2003 Koen joined the Multidrug Resistance (MDR) group of Piet Borst at the Netherlands Cancer Institute and initially focused on the pharmacological roles of MRP3/ABCC3. The last couple of years he has set up methods employing metabolomics to search for the physiological substrates of the MRPs/ABCCs. Using this metabolic approach several new substrates of MRP2 (ABCC2), MRP3 (ABCC3) and BCRP (ABCG2) have been identified. Recently it has become clear that PXE is a metabolic disease caused by the absence of a factor in blood normally provided by MRP6 from the liver. The new technology developed might offer new opportunities to identify this as yet unknown factor transported by MRP6 (ABCC6) into the circulation and a major effort will be made to find it.

Interview with Dr. van de Wetering 
View the webinar "Searching for the ABCC6 Substrate"
 

Areas of Interest

Assay Development
PXE and the Metabolism
 

Publications

Krumpochova P, Sapthu S, Brouwers JF, de Haas M, de Vos R, Borst P, van de Wetering K. Transportomics: screening for substrates of ABC transporters in body fluids using vesicular transport assays. FASEB J. 2012 Feb;26(2):738-47.

Fülöp K, Jiang Q, van de Wetering K, Pomozi V, Szabó PT, Arányi T, Sarkadi B, Borst P, Uitto J, Váradi A. ABCC6 does not transport vitamin K3-glutathione conjugate from the liver: Relevance to pathomechanisms of pseudoxanthoma elasticum. Biochem Biophys Res Commun. 2011 Nov 25;415(3):468-71.

Borst P, van de Wetering K, Schlingemann R. Does the absence of ABCC6 (Multidrug Resistance Protein 6) in patients with Pseudoxanthoma elasticum prevent the liver from providing sufficient vitamin K to the periphery? Cell Cycle. 2008 Jun 1; 7(11):1575-9. Free article at Journal Website.